Tissue-specific transcriptional regulation has diverged significantly between human and mouse

Odom, D.T., Dowell, R.D., Jacobsen, E.S., Gordon, W., Danford, T.D., MacIsaac,K., Rolfe, A., Conboy, C.M., Gifford, D.K., Fraenkel, E

Abstract

We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four tissue-specific transcription factors (FOXA2, HNF1A, HNF4A and HNF6) to 4,000 orthologous gene pairs in hepatocytes purified from human and mouse livers. Despite the conserved function of these factors, from 41% to 89% of their binding events seem to be species specific. When the same protein binds the promoters of orthologous genes, approximately two-thirds of the binding sites do not align.

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