Sample THEME output is provided below. For each hypothesis tested THEME provides: 1. A text logo of the unrefined hypothesis. 2. A text logo of the best refined hypothesis and the optimal value of the hypothesis weighting (Beta) determined by cross-validation 3. The mean cross-validation error achieved by the best refined hypothesis 4. The log-likelihood ratio score used as a matching threshold by the SVM classifier and the number of true and false positives in the input set at this threshold 5. A list of matches to the motif in the input set Matches are output in the following format: sequence_name------> offset_1: matching_sequence .... offset_n: matching_sequence -------BEGIN SAMPLE OUTPUT--------- Loading Markov background file from /cluster/macisaac/con/Utilities/human_6th_order.bg Processing input sequences.... ---------------New Hypothesis--------------- Unrefined Hypothesis: ..RGGTCA (0) Refined Hypothesis: ..rGGtCA (88) Optimal Beta: 0.333333 Mean 3-fold cv error: 0.418485 LLR match threshold: 0.773461 True positives: 51 False Negatives: 13 Motif matches in positive input set: NM_004590------> 139: GGAGGTCA 697: CAAGGTCA NM_001622------> 118: TGCCCTTG NM_013952------> 90: CAAGGTCA 421: TGACCTTT 584: TGACCTTC 666: AGAGGTCA 755: AGGGGTCA NM_004768------> 192: TGCCCTTG NM_000040------> 737: TGACCTTT 794: ACAGGTCA NM_025032------> 483: TGCCCTTG 779: AAGGGTCA 915: TGACCCTT 1092: CAGGGTCA NM_000773------> 560: CCAGGTCA NM_006402------> 765: AGGGGTCA NM_000638------> 512: AAAGGTCA 582: TTAGGTCA NM_002490------> 132: TGACCCTC 179: TGACCTCA 1258: ATAGGTCA 1322: CTAGGTCA NM_018045------> 418: TGACCTTT 1103: TAAGGTCA NM_005513------> 1161: TGACCCCG NM_018295------> 651: TGACCTGG 1339: TGACCCTC NM_004512------> 52: TGACCTGG NM_015471------> 373: GAGGGTCA 762: TGACCTTG NM_031479------> 429: CAGGGTCA 979: CCAGGTCA 1006: GAGGGTCA NM_030579------> 14: TGAGGTCA NM_002633------> 85: TGACCTTG 613: TGACCCTC NM_006895------> 366: TGACCTTC 487: TGACCTCG 943: TGACCTTT NM_002790------> 114: TGACCCTT NM_000504------> 250: GAAGGTCA 1196: AGAGGTCA NM_018129------> 735: TGACCTCT NM_021969------> 141: AAAGGTCA 767: CAAGGTCA 1271: TGAGGTCA NM_015940------> 31: TGACCTCA 1121: TAGGGTCA NM_016327------> 107: TGACCTTC 1288: TGACCTTT NM_016953------> 33: TGACCCTG NM_000029------> 477: TGACCCTG 505: TGACCTTC NM_001671------> 778: TGACCCTG 978: TCAGGTCA 1074: CAGGGTCA NM_000606------> 543: AGAGGTCA NM_014748------> 486: AGGGGTCA NM_000602------> 510: TGACCTGG 664: AAAGGTCA NM_001610------> 153: CCAGGTCA NM_001914------> 191: ACAGGTCA 1087: TGACCCCG NM_000106------> 511: TGACCCTT 839: TGACCTTG 880: TGACCTTC NM_004433------> 569: TCAGGTCA 1208: GAGGGTCA NM_001155------> 308: GAGGGTCA 858: TGACCTGT NM_138482------> 1021: TGACCCCG 1226: CAAGGGCA NM_002217------> 194: TAAGGTCA 881: TGACCCTG 1341: TGACCTCT NM_002218------> 489: TGACCTCA NM_018148------> 958: TGACCTGG 1390: TGCCCTTG NM_001859------> 490: CAGGGTCA 1142: TGACCTGG 1329: TGACCTTG NM_016518------> 514: TGACCTCA NM_013249------> 324: TGACCCTC 784: TGACCCTC NM_015950------> 5: CAAGGTCA 735: TGACCTCG NM_019043------> 397: CGGGGTCA NM_000416------> 482: CGGGGTCA NG_000853------> 501: TGACCCTT 829: TGACCTTG 870: TGACCTTC NM_032562------> 77: TGACCTCT 874: AAGGGTCA 1375: TGAGGTCA NM_005952------> 8: TGACCCTG NM_015216------> 257: TGACCTCA NM_005951------> 102: CAGGGTCA 164: AGAGGTCA 1066: GGAGGTCA